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Hemato-oncology
How myeloproliferative neoplasms patients’ experience and expectations differ from physicians’: the international MPN Landmark survey
Ja Min Byun, Soo-Mee Bang, Eun-Ji Choi, Ki-Seong Eom, Chul Won Jung, Hye-seon Kim, Jiwon Park, Chul Won Choi
Korean J Intern Med. 2022;37(2):444-454. Published online February 28, 2022
Background/Aims: Recent advances in the understanding of the pathophysiology of myeloproliferative neoplasms (MPN) were not paralleled with advances in treatment options; thus many questions regarding optimal MPN management remain unanswered. Here, we report the results of descriptive survey study o..
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The efficacy of EGFR-tyrosine kinase inhibitor in non-small cell lung cancer patients with synchronous brain metastasis: a real-world study
Jin-Hyuk Choi, Yong Won Choi, Hyun Woo Lee, Seok Yun Kang, Geum Sook Jeong, Mi Sun Ahn, Young-Taek Oh, O kyu Noh, Se-Hyuk Kim, Tae Hoon Roh, Seung Soo Sheen
Korean J Intern Med. 2022;37(2):434-443. Published online February 16, 2022
Background/Aims: The optimal treatment (Tx) for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) remains to be determined.
Methods: A retrospective review was conducted on 77 NSCLC patients with synchronous BM who underwent first-..
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Nephrology
The presence of simple renal cysts is associated with an increased risk of albuminuria in young adults
Hyo Jin Boo, Jung Eun Lee, Son Mi Chung, Hye Ryoun Jang, Wooseong Huh, Dae Joong Kim, Yoon-Goo Kim
Korean J Intern Med. 2022;37(2):425-433. Published online December 7, 2021
Background/Aims: The prevalence of simple renal cysts increases with age; however, they are occasionally found in adults aged < 40 years. This cross-sectional study evaluated the clinical significance of simple cysts in young adults, focusing on their associations with hematuria and albuminuria.
Me..
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Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells
Sun Woo Lim, Kyung Woon Kim, Bo Mi Kim, Yoo Jin Shin, Kang Luo, Yi Quan, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2022;37(2):411-424. Published online September 16, 2021
Background/Aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) exert powerful therapeutic..
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Endocrinology-metabolism
Clinical features and signaling effects of RET D631Y variant multiple endocrine neoplasia type 2 (MEN2)
Ji-young Lee, Su Yeon Kim, Kwan Hoon Jo, Eun Yeong Mo, Eun Sook Kim, Hye Soo Kim, Je Ho Han, Sung-dae Moon
Korean J Intern Med. 2022;37(2):398-410. Published online December 15, 2021
Background/Aims: Germline mutations of the rearranged during transfection (RET) gene cause multiple endocrine neoplasia type 2 (MEN2). About 85% of RET mutations in MEN2 occur in codon Cys634. The RET D631Y mutation has recently been discovered, and we have studied its molecular expres..
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Pulmonology
Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis
Heemoon Park, Jaeyoung Cho, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sun Mi Choi
Korean J Intern Med. 2022;37(2):387-397. Published online December 7, 2021
Background/Aims: The prevalence and effects of airway diseases, including asthma, eosinophilic bronchitis (EB), chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) have not been thoroughly studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to evalu..
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Diagnostic index for acute eosinophilic pneumonia without bronchoscopy in military smokers
Sunmin Park, Deokjae Han, Ji Eun Lee, Duck Hyun Ryu, Hyung-Jun Kim
Korean J Intern Med. 2022;37(2):377-386. Published online December 16, 2021
Background/Aims: Acute eosinophilic pneumonia (AEP) is common among military smokers; however, bronchoscopy is required for the diagnosis. We aimed to derive and validate a scoring system to diagnose AEP without bronchoscopy.
Methods: We conducted a retrospective study including patients diagnosed ..
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Efficacy of lower dose pirfenidone for idiopathic pulmonary fibrosis in real practice: a retrospective cohort study
Hyeontaek Hwang, Jung-Kyu Lee, Sun Mi Choi, Yeon Joo Lee, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Young Whan Kim, Jong Sun Park
Korean J Intern Med. 2022;37(2):366-376. Published online July 27, 2021
Background/Aims: Pirfenidone slows the progression of idiopathic pulmonary fibrosis (IPF). We investigated its efficacy and safety in terms of dose and disease severity in real-world patients with IPF.
Methods: This multicenter retrospective cohort study investigated 338 patients treated with pirfe..
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Cardiology
The current status and outcomes of in-hospital P2Y12 receptor inhibitor switching in Korean patients with acute myocardial infarction
Keun-Ho Park, Myung Ho Jeong, Hyun Kuk Kim, Young-Jae Ki, Sung Soo Kim, Youngkeun Ahn, Hyun Yi Kook, Hyo-Soo Kim, Hyeon Cheol Gwon, Ki Bae Seung, Seung Woon Rha, Shung Chull Chae, Chong Jin Kim, Kwang Soo Cha, Jong Seon Park, Jung Han Yoon, Jei Keon Chae, Seung Jae Joo, Dong-Joo Choi, Seung Ho Hur, In Whan Seong, Myeong Chan Cho, Doo Il Kim, Seok Kyu Oh, Tae Hoon Ahn, Jin Yong Hwang; on behalf of the KAMIR-NIH registry investigators
Korean J Intern Med. 2022;37(2):350-365. Published online January 12, 2022
Background/Aims: While switching strategies of P2Y12 receptor inhibitors (RIs) have sometimes been used in acute myocardial infarction (AMI) patients, the current status of in-hospital P2Y12RI switching remains unknown.
Methods: Overall, 8,476 AMI patients who underwent successful revascularization..
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Clinical outcome in patients with end-stage heart failure who underwent continuous-flow left ventricular assist devices in a single center
Yoonjee Park, Darae Kim, Jeong Hoon Yang, Yang Hyun Cho, Jin-Oh Choi, Eun-Seok Jeon
Korean J Intern Med. 2022;37(2):340-349. Published online December 7, 2021
Background/Aims: The continuous flow left ventricular assist device (cf-LVAD) has improved the survival of chronic end-stage heart failure (HF) patients. Here we describe our clinical experience of the initial 50 LVAD patients from a single center.
Methods: A total of 50 patients underwent LVAD imp..
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Gastroenterology
Rectal NSAIDs-based combination modalities are superior to single modalities for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a network meta-analysis
Tae Young Park, Hyun Kang, Geun Joo Choi, Hyoung-Chul Oh
Korean J Intern Med. 2022;37(2):322-339. Published online February 16, 2022
Background/Aims: Different modalities have been employed to reduce the risk and severity of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). However, there has been a paucity of studies comparing the efficacy of various prophylactic modalities for preventing PEP. This n..
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Positive fecal immunochemical test results are associated with non-colorectal cancer mortality
Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
Korean J Intern Med. 2022;37(2):313-321. Published online September 29, 2021
Background/Aims: Studies have reported an association between fecal occult blood and increased all-cause, non-colorectal cancer (CRC) as well as CRC mortality. This study aimed to determine whether positive fecal immunochemistry test (FIT) results are associated with death from various causes in the..
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Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program
Jun Yeop Lee, Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung
Korean J Intern Med. 2022;37(2):304-312. Published online December 16, 2021
Background/Aims: Helicobacter pylori infection is presumably associated with iron deficiency and iron deficiency anemia (IDA). This study aimed to evaluate the relationship between H. pylori infection and the decline in iron stores in non-elderly adults during their health check-ups.
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Gastroenterology
Prevalence and associated risk of advanced colorectal neoplasia in adults with sarcopenia
[letter]
Min Cheol Kim, Kyeong Ok Kim, Min Kyu Kang
Korean J Intern Med. 2022;37(2):294-303. Published online December 16, 2021
Background/Aims: Although several studies have shown that sarcopenia is associated with poor outcomes in colorectal cancer patients, the impact of sarcopenia on the development of colorectal neoplasia remains unclear. We aimed to evaluate the prevalence and association of colorectal neoplasia, espec..
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Gastroenterology
Two-dimensional shear wave elastography for assessing liver fibrosis in patients with chronic liver disease: a prospective cohort study
Hae Won Yoo, Sang Gyune Kim, Jae Young Jang, Jeong-Ju Yoo, Soung Won Jeong, Young Seok Kim, Boo Sung Kim
Korean J Intern Med. 2022;37(2):285-293. Published online December 7, 2021
Background/Aims: The objective of this study was to determine whether the newly developed two-dimensional shear wave elastography (2D-SWE, RS85, Samsung-shearwave imaging) was more valid and reliable than transient elastography (TE) for predicting the stage of liver fibrosis.
Methods: The study pro..
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Simple renal cysts: no longer simple?
Sang Heon Suh, Eun Hui Bae
Korean J Intern Med. 2022;37(2):283-284. Published online February 28, 2022
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Urgent need for novel antibiotics in Republic of Korea to combat multidrug-resistant bacteria
Hyo-Jin Lee, Dong-Gun Lee
Korean J Intern Med. 2022;37(2):271-280. Published online February 28, 2022
Multidrug resistance in bacteria is an important issue and is increasing in frequency worldwide because of the limitations of therapeutic agents. From 2010 to 2019, 14 new systemic antibiotics received regulatory approval in the United States. However, few new antibiotics have been introduced in Rep..
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Desensitization for the prevention of drug hypersensitivity reactions
Sung-Yoon Kang, Jeongmin Seo, Hye-Ryun Kang
Korean J Intern Med. 2022;37(2):261-270. Published online February 28, 2022
Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose. It can be used as a therapeutic strategy for patients with drug hypersensitivity when no comparable alternativ..
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The Korean Severe Asthma Registry (KoSAR): real world research in severe asthma
Sang-Heon Kim, Hyun Lee, So-Young Park, So Young Park, Woo-Jung Song, Joo-Hee Kim, Heung-Woo Park, You Sook Cho, Ho Joo Yoon; on behalf of the KoSAR investigators
Korean J Intern Med. 2022;37(2):249-260. Published online February 28, 2022
Severe asthma constitutes a serious health burden with significant morbidity and socioeconomic costs. The development and introduction of new biologics targeting type 2 inflammation changed the paradigm for management of severe asthma and initiated a biological era. These changes impose a challenge ..
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